Home> Archive> 2022> Volume 12 Number 3 (Aug. 2022)
IJSSH 2022 Vol.12(3): 182-187 ISSN: 2010-3646
doi: 10.18178/ijssh.2022.V12.1088

Transcranial Magnetic Stimulation (TMS) for the Treatment of Major Depressive Disorder: A Systematic Review

Qianyi Hou

Abstract—Major Depressive Disorder (MDD) is one of the major health problems commonly develop in adult years. Effective treatments typically include antidepressant medications, psychological therapies, complementary therapies, or a combination of several different methods. However, research into the effectiveness of Transcranial Magnetic stimulation (TMS) in treating MDD is limited. The current study aimed to perform a systematic review on the use of TMS for the treatment of MDD. This systematic review was conducted with randomized trials in which the effects of TMS compared with sham stimulation in adults who were diagnosed major depressive depression. Eighteen randomized controlled studies were included in this systematic review. The results across studies were relatively consistent, showing the high frequency rTMS was effective to treat MDD when applied to left dorsolateral prefrontal cortex (dlPFC), primary visual cortex, hand area of primary motor cortex, left dlPFC and dmPFC. Only four studies demonstrated that high frequency rTMS was ineffective to left dlPFC and both left and right dlPFC, and Theta Burst stimulation (TBS) to both left and right dlPFC was ineffective comparing with sham stimulation. The major limitations of the studies reviewed here are half of them didn’t apply double-blinded design and only focus on adults which might cause bias. Therefore, more high-quality double-blinded trials and trials which focus on other groups of people are needed to evaluate the effects of TMS treatment precisely.

Index Terms—Major depressive disorder (MDD), transcranial magnetic stimulation (TMS), systematic review, psychiatry.

Qianyi Hou is with Beijing Changping Xinxuedao Linchuan International School, China (e-mail: 774044814@qq.com).

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Cite: Qianyi Hou, "Transcranial Magnetic Stimulation (TMS) for the Treatment of Major Depressive Disorder: A Systematic Review," International Journal of Social Science and Humanity vol. 12, no. 3, pp. 182-188, 2022.


Copyright © 2022 by the authors. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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